THE MODE OF ACTION OF RADIOPROTECTIVE AGENTS

Journal Article · Thu Nov 01 04:00:00 EST 1962 · Annee Biologique (France)

OSTI ID:4657627

Kirrmann, J -M

Since the discovery in 1949 of the first chemical radioprotectors in the animal, there have been proposed different theories to explain the mechanism of the appearance of the radiolesions and the mode of action of radioprotectors. These theories are concisely reported. The mode of action of x rays on cells was explained first by the target theory aud then by the addition of the indirect effect theory. The mechanisms of radioprotection by anoxia proposed to explain the manner in which molecular oxygen can modify the types of radicals formed by irradiation are examined. The principal theories on the mechanism of chemical radioprotectors are the reduction theory, the competition theory, and the combination theory. These are briefly reviewed. The evidence of free radicals on the mechanism is indicated. 51 references. (J.S.R.)

• Research Organization: College de France, Paris
• NSA Number: NSA-17-038768
• OSTI ID: 4657627
• Journal Information: Annee Biologique (France), Journal Name: Annee Biologique (France) Vol. Vol: (4), 1; ISSN ANBLA
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

ANIMAL CELLS
ANIMALS
BIBLIOGRAPHY
BIOLOGY AND MEDICINE
CHEMICALS
FREE RADICALS
OXYGEN
QUANTITY RATIO
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIOCHEMISTRY
REDUCTION
TARGETS
X RADIATION