REMOTE CARCINOGENIC EFFECTS OF CERTAIN RADIOACTIVE COMPOUNDS

Journal Article · Sun Sep 01 04:00:00 EDT 1963 · Federation Proc., Transl. Suppl.

OSTI ID:4657626

Kochetkova, T A; Avrunina, G A; Sagaidak, N D

Insoluble compounds of Fe/sup 59/-ferric oxide, P/sup 32/-chromium phosphate, and Au/sup 198/-colloidal gold administered intratracheally to rats induced squamous cell carcinomas of the lung with metastases to the pleura and regional and mesenteric lymph nodes. Soluble solutions of Na/sup 24/ and Fe/sup 59/ or insoluble Fe/sup 59/-ferric oxide of low activity did not induce tumors within 24 months. Both the soluble and insoluble radioactive compounds caused degenerative changes and impaired permeability of the walls of the blood vessels followed by the development of perivascular and peribronchial sclerosis. Results indicate that insoluble radioactive compounds may create large depth doses of radiation in the foci of their deposition. (C.H.)

• Research Organization: Inst. of Industrial Health and Occupational Diseases, Academy of Medical Sciences, USSR
• NSA Number: NSA-17-038781
• OSTI ID: 4657626
• Journal Information: Federation Proc., Transl. Suppl., Journal Name: Federation Proc., Transl. Suppl. Vol. Vol: 22: Pt. II
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD VESSELS
CARCINOGENESIS
CHROMIUM PHOSPHATES
COLLOIDS
DIFFUSION
GOLD 198
IRON 59
IRON OXIDES
LABELLED COMPOUNDS
LUNGS
LYMPH NODES
LYMPH SYSTEM
METASTASES
PHOSPHORUS 32
RADIATION DOSES
RADIATION EFFECTS
RATS
SODIUM 24
SOLUBILITY
SOLUTIONS