ANTIBODY, LYSOZYME, AND COMPLEMENT LEVELS IN ANIMALS CHEMICALLY PROTECTED AGAINST X IRRADIATION

Journal Article · Mon Jul 01 04:00:00 EDT 1963 · Journal of Immunology (U.S.)

OSTI ID:4657592

Hook, W A; Toussaint, A J; Muschel, L H

Tests were conducted on the effects of protecting animals before irradiation with a mixture of 5 chemical agents, containing -SH groups or promoting anoxia, on certain serum components that may be related to natural immunity, such as normal antibody, lysozyme, and complement. Protection of guinea pigs or rabbits with this mixture against the lethal effects of x rays noticeably lessened the depressive effect of whole-body irradiation on normal serum levels of lysozyme, bacteriophage-neutralizing antibody, and bactericidal antibody. This was apparently caused by the so-called dosereducing effect of the agents. Neither protection nor irradiation seemed to have a significant effect on hemolytic complement titers of guinea pigs and rabbits. Reduction of a sublethal (500-r) x-ray dose to an estimated effective 250 r by the chemicals did not noticeably protect the immune antibody-forming mechanism of rabbits immunized during the radiosensitive stage of antibody formation. Protection against x irradiation afforded animals by the agents tested was attributed to several mechanisms. Diphenylamine, p-hydroxydiphenyl, and p-aminopropiophenone may protect tissue by lowering its oxygen content, whereas the sulfhydryl compounds cysteine and mercaptoethylamine may have the ability to trap free radicals. (BBB)

• Research Organization: Walter Reed Army Inst. of Research, Washington, D.C.
• NSA Number: NSA-17-038804
• OSTI ID: 4657592
• Journal Information: Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 91; ISSN JOIMA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINES
ANTIBODIES
BACTERIA
BACTERIOPHAGES
BIOLOGY AND MEDICINE
BLOOD SERUM
CYSTEINE
ENZYMES
FREE RADICALS
GUINEA PIGS
IMMUNITY
IRRADIATION
KETONES
LYSOZYME
MEA
ORGANIC SULFUR COMPOUNDS
PHENYL RADICALS
PROPIONIC ACID
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RADIOSENSITIVITY
TESTING
X RADIATION