IMMEDIATE AND LATE CHANGES IN CHROMOSOMES INDUCED IN THE BONE MARROW OF RATS IRRADIATED IN VIVO

Journal Article · Sun Jul 01 04:00:00 EDT 1962 · Minerva Fisioterap.

OSTI ID:4634617

Punturieri, E; Bosi, L; Castoldi, G L; Ricci, N; de Bellis, N

Squash preparations of chromosomes were obtained from the bone marrow cells of 39 female rats of the Morini strain at 6 hr, 4 days, and 30 days after whole-body x irradiation of the animals at a rate of 14 r/min to total doses of 50 to 400 r. Chromatid changes were most marked at 6 hr and, at that time, their frequency was proportional to the dose. These changes were less frequent at 4 days and absent at 30 days postirradiation. For example, at 6 hr the number of chromatid breaks was 124, 43, 19, and 8% greater than the control number at radiation doses of 400, were all below 3% and no chromatid injuries were noted at 30 days. The highest incidence of achromatic lesions (l1%) and polyploid mitoses (13%) were noted at 6 hr after the 200-r dose. In one rat exposed to 400 r, at 4 days two markedly anomalous chromosomes were seen which were of the type previously noted in urethane-treated mice. The absence of chromosome anomalies 30 days after irradiation indicates the selective elimination of cells with damaged chromosomes; however, the possibilities of the persistence of lines of cells with aberrations too slight to be detected morphologically cannot be overlooked. (BBB)

• Research Organization: Universita, Ferrara, Italy
• NSA Number: NSA-17-038816
• OSTI ID: 4634617
• Journal Information: Minerva Fisioterap., Journal Name: Minerva Fisioterap. Vol. Vol: 7
• Country of Publication: Country unknown/Code not available
• Language: Italian

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BODY
BONE MARROW
CARBAMATES
CHROMOSOMES
ETHYL RADICALS
MICE
MITOSIS
MUTATIONS
RADIATION DOSES
RADIATION EFFECTS
RATS
SEX
TOXICITY
URETHANE
X RADIATION