Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells

Journal Article · Thu May 01 00:00:00 EDT 1997 · Bioelectromagnetics

DOI:https://doi.org/10.1002/(SICI)1521-186X(1997)18:2<156::AID-BEM8>3.3.CO;2-2· OSTI ID:462584

Lai, H; Singh, N P ^[1]

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1. Univ. of Washington, Seattle, WA (United States)

Acute exposure of rats to a 60 Hz magnetic field caused a dose-dependent increase in DNA strand breaks in brain cells of the animals (assayed by a microgel electrophoresis method at 4 h postexposure). An increase in single-strand DNA breaks was observed after exposure to magnetic fields of 0.1, 0.25, and 0.5 mT, whereas an increase in double-strand DNA breaks was observed at 0.25 and 0.5 mT. Because DNA strand breaks may affect cellular functions, lead to carcinogenesis and cell death, and be related to onset of neurodegenerative diseases, the data may have important implications for the possible health effects of exposure to 60 Hz magnetic fields.

• Sponsoring Organization: National Inst. of Environmental Health Sciences, Research Triangle Park, NC (United States)
• OSTI ID: 462584
• Journal Information: Bioelectromagnetics, Journal Name: Bioelectromagnetics Journal Issue: 2 Vol. 18; ISSN 0197-8462; ISSN BLCTDO
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL MODELS
GENETIC EFFECTS
HZ RANGE
MAGNETIC FIELDS
STRAND BREAKS