THE EFFECT OF IONIZING RADIATIONS ON THE CARDIAC MUSCLE OF MAMMALS

Journal Article · Sun Sep 01 04:00:00 EDT 1963 · Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals

OSTI ID:4623333

Tarapina, T V

A total of 200 white rats was exposed to whole-body x-irradiation (600 r) and then sacrificed at different times (8 hr to 8 months after the irradiation). The hearts were examined for initial (reactive), and distrophic alterations of the cardiac muscle such as fragmentation, granular decomposition, fatty degeneration and variations in the glycogen level. During the first two days after irradiation, no alterations are found in the myocardium. They begin to appear after 4 to 5 days and become serious at the 8th day. Swelling and disjunction ( combing'') of the myofibrils took place, accompanied by decomposition of the nuceli. Eventually, myofibrils underwent vacuolization and granular decomposition, while the subepicardial layer became infiltrated with blood. The glycogen content of the cardiac muscle was only slightly affected by the sugar content on the blood and in the food; myocardium, however, was more sensitive to a loss of glycogen than liver or skeletal muscles. No change in the glycogen content of the heart was detectable during the first post-irradiation period; 5 to 7 days after irradiation, however, a marked decrease in glycogen is observed. At this stage, glycogen was found accumulated in droplets and irregular masses within the cells. This decrease was still present 2 to 5 months after the irradiation, although there was a tendency toward an increase to normal glycogen values. The cardiac muscle was concluded not to be a morphologically radioresistant structure; and, therefore, it undergoes both reactive and destructive alterations upon irradiation with x rays. (TTT)

• Research Organization: Pavlov Medical Inst., Ryazan, USSR
• NSA Number: NSA-17-040580
• OSTI ID: 4623333
• Journal Information: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals, Journal Name: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals Vol. Vol: 152; ISSN DANKA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ANIMALS
BIOLOGY AND MEDICINE
BLOOD
BODY
CELL NUCLEI
CYTOLOGY
DECOMPOSITION
GLYCOGEN
HEART
IRRADIATION
LIVER
METABOLISM
MUSCLES
NUCLEIC ACIDS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOSENSITIVITY
RATS
SUGARS
VARIATIONS
X RADIATION