DNA polymerase having modified nucleotide binding site for DNA sequencing
Patent
·
OSTI ID:458581
A modified gene encoding a modified DNA polymerase is disclosed. The modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase. 6 figs.
- Research Organization:
- Harvard University
- DOE Contract Number:
- FG02-88ER60688
- Assignee:
- Harvard Coll., Cambridge, MA (United States)
- Patent Number(s):
- US 5,614,365/A/
- Application Number:
- PAN: 8-337,615
- OSTI ID:
- 458581
- Country of Publication:
- United States
- Language:
- English
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