skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: DNA polymerase having modified nucleotide binding site for DNA sequencing

Abstract

Modified gene encoding a modified DNA polymerase wherein the modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase.

Inventors:
 [1];  [2]
  1. Cambridge, MA
  2. Chestnut Hill, MA
Publication Date:
Research Org.:
Harvard University
OSTI Identifier:
870881
Patent Number(s):
US 5614365
Assignee:
President & Fellow of Harvard College (Cambridge, MA)
DOE Contract Number:  
FG02-88ER60688
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
dna; polymerase; modified; nucleotide; binding; site; sequencing; encoding; incorporates; dideoxynucleotides; 20-fold; compared; corresponding; deoxynucleotides; naturally-occurring; dna polymerase; binding site; dna sequencing; modified polymer; /435/530/999/

Citation Formats

Tabor, Stanley, and Richardson, Charles. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States: N. p., 1997. Web.
Tabor, Stanley, & Richardson, Charles. DNA polymerase having modified nucleotide binding site for DNA sequencing. United States.
Tabor, Stanley, and Richardson, Charles. Wed . "DNA polymerase having modified nucleotide binding site for DNA sequencing". United States. https://www.osti.gov/servlets/purl/870881.
@article{osti_870881,
title = {DNA polymerase having modified nucleotide binding site for DNA sequencing},
author = {Tabor, Stanley and Richardson, Charles},
abstractNote = {Modified gene encoding a modified DNA polymerase wherein the modified polymerase incorporates dideoxynucleotides at least 20-fold better compared to the corresponding deoxynucleotides as compared with the corresponding naturally-occurring DNA polymerase.},
doi = {},
url = {https://www.osti.gov/biblio/870881}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {1}
}

Patent:

Save / Share: