DT-diaphorase induction by lead acetate in the liver of rats
Journal Article
·
· Bulletin of Environmental Contamination and Toxicology
- Nagasaki Univ. (Japan)
DT-diaphorase(NAD(P)H:(quinone acceptor)oxidoreductase) is a cytosolic enzyme, which is localized mainly in liver, kidney, and gastrointestinal tract suggested that DT-diaphorase has a role as a cellular control devise against radical formation. Moreover it is considered that DT-diaphorase has an important role in the cellular defense mechanism against cytotoxic and mutagenic compounds. This enzyme is induced by aromatic hydrocarbons such as 3-methylcholanthrene and antioxidants, and is an interesting enzyme from drug metabolism and toxicological aspects. Another series of studies first reported that the treatment of organotin compounds induces hepatic DT-diaphorase activity accompanied by thymus atrophy in rats. Second, the induction ability of hepatic DT-diaphorase of rats treated with lead acetate (PbAc) is high among various metals. Although organotin compounds produce both thymus atrophy and increased DT-diaphorase activity similar to 3-MC, PbAc causes no significant change in thymus weight. These findings suggest that there is a different mechanism involved in the induction of DT-diaphorase with PbAc than with organotin compounds. In the present study, the induction mechanism of DT-diaphorase by PbAc in the liver of rats was investigated. 16 refs., 4 figs.
- OSTI ID:
- 456753
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology, Journal Name: Bulletin of Environmental Contamination and Toxicology Journal Issue: 1 Vol. 57; ISSN 0007-4861; ISSN BECTA6
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:5863333