EFFECT OF STRAIN AND DIET ON THE THIRTY-DAY MORTALITY OF X-IRRADIATED GERM- FREE MICE

Journal Article · Thu Mar 31 23:00:00 EST 1966 · Radiation Research (U.S.)

DOI:https://doi.org/10.2307/3571845· OSTI ID:4547205

Walburg, Jr., H. E.; Mynatt, E. I.; Robie, D. M.

Germ-free and conventionally reared mice of the inbred RFM and non-inbred ICR and CF No. 1 strains were exposed at ≈ 100 r/min to 500-1000 r whole-body X-rays (half-value layer 1.0 mm Cu). In each strain, germfree mice had a higher LD_50/30 than their conventional counterparts, but the difference in LD_50/30 between germfree and conventional mice varied with strain from 147 r for RFM males to 34 r for CF No. 1 mice. The LD_50/30 of different strains varied only one-half as much in germfree mice as in the conventional mice, and the order of strain radiosensitivity was different for conventional and germfree mice. Supplementation of the autoclaved diet with a filter-sterilized synthetic diet increased the LD_50/30 of germfree ICR mice from 790 to 900 r, changed the slope of the mortality curve and the mean survival time, and decreased weight loss after irradiation.

• Research Organization: Oak Ridge National Lab., TN
• Sponsoring Organization: US Atomic Energy Commission (AEC)
• DOE Contract Number: W-7405-ENG-26
• NSA Number: NSA-20-022730
• OSTI ID: 4547205
• Report Number(s): ORNL-P-1372
• Journal Information: Radiation Research (U.S.), Journal Name: Radiation Research (U.S.) Journal Issue: 4 Vol. Vol: 27; ISSN 0033-7587; ISSN RAREAE
• Country of Publication: United States
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
DIET
FOOD
GENETICS
GERM-FREE
IRRADIATION
MICE
MORTALITY
RADIATION DOSES
RADIATION INJURIES
RADIOSENSITIVITY
Radiation Effects on Tissues
STERILIZATION
SURVIVAL TIME
VARIATIONS
WEIGHT
X RADIATION