SURVIVAL STUDIES OF WHOLE-BODY X-IRRADIATED GERMFREE (AXENIC) MICE

Journal Article · Fri Nov 01 04:00:00 EST 1963 · Radiation Res.

DOI:https://doi.org/10.2307/3571378· OSTI ID:4157552

Wilson, B R

The response of germfree (axenic) Swiss-Webster mice to whole-body x irradiation at 500 to 3000 r was compared to that of conventional Swiss-Webster mice. The LD/sub 50(30)/ dose for axenic mice was 705 r, and that for conventional mice was 660 r. The slopes of the dose-response curves were the same. However, the survival times at a given dose were markedly different. On a log- log scale the relation between dose and survival time is linear, the 650- to 3000- r range producing mean survival times from 15 to 7 days. The survival time of conventional mice is about 4 days less than for axenic mice in the 500 to 1000-r range and then drops sharply to a plateau of between 3 and 4 days. (auth)

• Research Organization: Univ. of Notre Dame, Ind.
• NSA Number: NSA-18-001426
• OSTI ID: 4157552
• Journal Information: Radiation Res., Journal Name: Radiation Res. Vol. Vol: 20
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
CONFIGURATION
CONTROL
DIAGRAMS
FURNACES
HEAT TREATMENTS
LABORATORY EQUIPMENT
LETHAL DOSE
METALLURGY
METALS
MICE
POWDER METALLURGY
RADIATION DOSES
RADIOSENSITIVITY
SURVIVAL TIME
VARIATIONS
WELDING
X RADIATION