Corrections to the paper {open_quotes}fitting the armitage-doll model to radiation-exposed cohorts and implications for population cancer risks{close_quotes}
- National Radiological Protection Board, Oxon (United Kingdom)
- Childhood Cancer Research Group, Oxford (United Kingdom)
- Berkeley Technology Centre, Glos (United Kingdom)
- Univ. of Rochester School of Medicine, NY (United States)
A recent paper analyzed patterns of cancer in the Japanese atomic bomb survivors and three other groups exposed to radiation by fitting the so-called multistage model of Armitage and Doll. The paper concluded that the incidence of solid cancer could be described adequately by a model in which up to two stages affected by radiation were assumed but that the data for leukemia within the bomb survivors might not be so well fitted. This was in part because of a failure to account for the observed linear-quadratic dose response that has been observed in the Japanese cohort. It has recently come to our attention that there was a mistake in the fits of the model with two adjacent radiation-affected stages, whereby the quadratic coefficient in dose was being set to zero in all the fits. This paper provides corrections in the calculations for the model and discusses the results.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 45276
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 137; ISSN 0033-7587; ISSN RAREAE
- Country of Publication:
- United States
- Language:
- English
Similar Records
Armitage-Doll two-stage model: Implications and extension
Threshold models in radiation carcinogenesis