Murine nuclear angiogaphy with multiwire proportional gamma camera and Ta-178
Journal Article
·
· Journal of Nuclear Medicine
OSTI ID:447744
- Proportional Technologies, Inc., Houston, TX (United States)
Genetic manipulation focuses in the murine animal model is generating a revolution in cardiovascular research. Thus, a serious need is emerging for micro imaging techniques capable of quantifying cardiovascular function in these very small animals and conventional radiographic and echocardiographic imaging equipment is very difficult to adapt for this application. A multiware proportional gamma camera (MWGC) and short lived generator produced agent Ta-178 have been developed which provide high quality ventricular function assessment in humans. We have investigated adaptation of this technology to murine nuclear angiography studies. Intrinsic advantages of essentially unlimited magnification through use of pinhole imaging geometry, high framing rate, and accurate count based quantification of ventricular function are provided. The increased rate capability and resolution of the MWGC and short half life of Ta-178 are also significant advantages. Monte-Carlo simulations of pinhole geometries for various pinhole sizes have been carried out. For the pinhole size of 2.0 mm diameter, 12.5 mm object to pinhole distance and 10 fold magnification an in-vivo image resolution of 1.9 mm FWHM and a sensitivity of 44,000 cps/mCi were obtained. High quality human first pass radionuclide angiography (FPRA) is obtained with a parallel hole lead collimator providing 18 mm FWHM human cardiac image resolution and 81,000 cps/mCi intrinsic sensitivity. Taking into account the 10 fold smaller ventricular dimension, 4 fold higher heart rate, and 10 fold lesser tissue traversal similar relative image resolution, temporal resolution and image statistics can be achieved with much cleaner scatter-free images therefore, high quality FPRA imaging of the murine heart is feasible.
- OSTI ID:
- 447744
- Report Number(s):
- CONF-960659--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 37; ISSN 0161-5505; ISSN JNMEAQ
- Country of Publication:
- United States
- Language:
- English
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