Coded-aperture imaging of the heart

Journal Article · Tue Apr 01 04:00:00 EST 1980 · J. Nucl. Med.; (United States)

OSTI ID:5422671

Rogers, W L; Koral, K F; Mayans, R; Leonard, P F; Thrall, J H; Brady, T J; Keyes, Jr, J W

Coded-aperture imaging of the heart combines the advantages of tomography with good sensitivity, high resolution, and accurate size scaling. Since the images are multiplexed, the method may be adapted to small, portable cameras for bedside use without sacrificing image resolution. A new coded aperture designed especially for cardiac imaging has been constructed and tested. This aperture incorporates significant improvements over previous designs. Longitudinal tomograms are calculated at 1-cm intervals using a modified ART algorithm. Experimental lateral resolution at 140 keV with a portable scintillation camera is 3.8 mm FWHM at 4 cm, and 7.8 mm FWHM at 12 cm. Depth resolution determined from a sloping line source is 1.1 cm FWHM at 4 cm, and 2.9 cm at 12 cm. The calculated point-source sensitivities in air at 4 cm and 12 cm, respectively, are 20 and 8 cps/..mu..Ci. Images of good diagnostic quality have been obtained in phantoms and in a dog model of acute myocardial infarction, using thallium-201, technetium-99m pyrophosphate, and gated ventricular blood-pool imaging with Tc-labeled red blood cells. Preliminary studies in humans confirm the good results in animals.

• Research Organization: Univ. of Michigan Medical Center, Ann Arbor
• OSTI ID: 5422671
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

440101 -- Radiation Instrumentation-- General Detectors or Monitors & Radiometric Instruments
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
APERTURES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DESIGN
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EXPERIMENTAL DATA
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMAGES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MEASURING INSTRUMENTS
MOCKUP
MUSCLES
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
OPENINGS
ORGANS
OXYGEN COMPOUNDS
PHANTOMS
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RADIATION DETECTORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESOLUTION
SCINTILLATION COUNTERS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
STRUCTURAL MODELS
TABLES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY
VERTEBRATES
YEARS LIVING RADIOISOTOPES