4-[F-18]fluoroproline: A potential tracer for collagen synthesis. Radiosynthesis and biological evaluation
Journal Article
·
· Journal of Nuclear Medicine
OSTI ID:447726
- Institut fuer Nuklearchemie, KFA Juelich (Germany)
- Nuklearmedizinische Klinik der TU Muenchen (Germany); and others
Proline is an important constituent of the structural protein collagen. It has been shown that its fluorinated analogs (2S,4S)- and particularly (2S,4R)-4-fluoroproline are also incorporated into collagen (Gottlieb et al., Biochemistry (1965), 4: 2507). 4-[F-18]fluoroproline is therefore a potential probe for studying abnormal collagen synthesis e. g. in tumors, lung fibrosis and liver cirrhosis. We have evaluated the two diastereomeric forms using a transplantable osteosarcoma in mice as an in vivo model for elevated collagen synthesis, and a MCF 7 mamma carcinoma cell line for monolayer incubation studies.
- OSTI ID:
- 447726
- Report Number(s):
- CONF-960659--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 37; ISSN 0161-5505; ISSN JNMEAQ
- Country of Publication:
- United States
- Language:
- English
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