Lack of association between schizophrenia and the CYP2D6 gene polymorphisms
Journal Article
·
· American Journal of Medical Genetics
- Univ. of Liverpool (United Kingdom); and others
Approximately 5-10% of the Caucasian population lack the P450 isoform, CYP2D6. This polymorphism may be of importance in determining individual susceptibility to Parkinson`s disease. In this journal, Daniels et al. recently reported a negative association between the CYP2D6 gene locus and schizophrenia, a disease characterized by dopamine overactivity. It is important to exclude such an association because CYP2D6 is expressed in the brain and it is involved in dopamine catabolism. Between 1992 and 1993, we also performed a study similar to that, and reached the same conclusion. 7 refs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 447670
- Journal Information:
- American Journal of Medical Genetics, Vol. 67, Issue 2; Other Information: PBD: 9 Apr 1996
- Country of Publication:
- United States
- Language:
- English
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