No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT)

Journal Article · Mon Feb 27 04:00:00 EST 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600115· OSTI ID:443802

Daniels, J; Williams, J; Asherson, P; McGuffin, P; Owen, M ^[1]

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1. Univ of Wales College of Medicine, Cardiff (United Kingdom)

It has been suggested that the cytochrome P450 mono-oxygenase, debrisoquine 4-hydroxylase, is involved in the catabolism and processing of neurotransmitters subsequent to their reuptake into target cells. It is also thought to be related to the dopamine transporter that acts to take released dopamine back up into presynaptic terminals. The present study used the association approach to test the hypothesis that mutations in the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT) confer susceptibility to schizophrenia. There were no differences in allele or genotype frequencies between patients and controls in the mutations causing the poor metaboliser phenotype in CYP2D6. In addition there was no association found between schizophrenia and a 48 bp repeat within the 3{prime} untranslated region of DAT. 18 refs., 2 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 443802
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 1 Vol. 60; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CYTOCHROMES
DOPAMINE
GENE MUTATIONS
GENES
GENOTYPE
HEREDITARY DISEASES
HYDROXYLASES
MAN
MENTAL DISORDERS
MUTATION FREQUENCY
NERVOUS SYSTEM DISEASES
OXIDOREDUCTASES
PHENOTYPE
STATISTICS