Association study between schizophrenia and dopamine D3 receptor gene polymorphism

Journal Article · Fri Jul 26 04:00:00 EDT 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19960726)67:4<366::AID-AJMG9>3.3.CO;2-V· OSTI ID:539389

Tanaka, Toshihisa; Takahashi, Makoto; Maeda, Masaya ^[1]

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1. Niigata Univ. (Japan); and others

Crocq et al. reported the existence of an association between schizophrenia and homozygosity of a BalI polymorphism in the first exon of the dopamine D3 receptor (DRD3) gene. In response to this report, further studies were conducted; however, these studies yielded conflicting results. In the present study, we examined 100 unrelated Japanese schizophrenics and 100 normal controls to determine any association between this polymorphism and schizophrenia. Results suggest that neither allele nor genotype frequencies of the DRD3 gene in the schizophrenics as a whole are significantly different from those of the controls. Further, we found no association between any allele or genotype and any clinical subtype based on family history of schizophrenia and age-at-onset. A significantly high frequency of homozygosity of a dopamine D3 receptor gene allele was not observed in the schizophrenics as a whole, or in clinical subtypes. Our results suggest that an association between the dopamine D3 receptor gene and schizophrenia is unlikely to exist. 26 refs., 1 tab.

• OSTI ID: 539389
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 4 Vol. 67; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACIDS
BEHAVIOR
DNA-CLONING
DOPAMINE
ETIOLOGY
EXONS
GENE MUTATIONS
GENETIC MAPPING
GENOTYPE
HEREDITARY DISEASES
JAPAN
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
PATIENTS
PSYCHOTROPIC DRUGS
RECEPTORS