Assessment of association of D3 dopamine receptor MscI polymorphism with schizophrenia: Analysis of symptom ratings, family history, age at onset, and movement disorders

Journal Article · Fri Sep 20 04:00:00 EDT 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19960920)67:5<455::AID-AJMG3>3.0.CO;2-J· OSTI ID:539225

Gaitonde, E J; Mollon, J D ^[1]; McKenna, P J ^[2]

---

1. Cambridge Univ. (United Kingdom)
2. Fulbourn Hospital, Cambridge (United Kingdom); and others

Several studies have reported an association between schizophrenia and homozygosity for the MscI restriction site in exon 1 of the D3 dopamine receptor gene, but other studies have failed to find this association. Recent reports have suggested that the association is most salient in male patients with a family history of schizophrenia. We examined this restriction site in a group of schizophrenic patients (n = 84) and in normal controls (n = 77). Patients were subdivided according to demographic and clinical features, particular attention being paid to movement disorders. No significant difference in allelic or genotypic distribution was seen between the two groups. No association was seen between homozygosity and a positive family history, age at onset of illness, clinical subtype, negative symptom score, or movement disorder scores. 33 refs., 2 tabs.

• OSTI ID: 539225
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 5 Vol. 67; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AGE DEPENDENCE
BEHAVIOR
BIOLOGICAL MARKERS
DNA SEQUENCING
DNA-CLONING
DOPAMINE
GENE MUTATIONS
GENETIC MAPPING
GENOTYPE
HEREDITARY DISEASES
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
PATIENTS
PHENOTYPE
POLYMERASE CHAIN REACTION
RECEPTORS
STATISTICS