Irradiation, methotrexate toxicity, and the treatment of meningeal leukaemia

Journal Article · Sat Sep 29 04:00:00 EDT 1973 · Lancet, v. 2, no. 7831, pp. 703-707

OSTI ID:4436752

Duttera, M J; Bleyer, W A; Pomeroy, T C; Leventhal, C M; Leventhal, B G

Thirty one patients with meningeal leukemia were randomized to therapy with intrathecal methotrexate with and without 2400 R to the cranial valut. Remissions were achieved in 29 patients. Remission duration was significantly longer (234+ days) in the group receiving methotrexate alone than in those receiving methotrexate and irradiation (125 days). A spectrum of methotrexate toxicity was seen after intrathecal administration ranging in severity from chemical arachnoiditis which was common (17 patients) through transient paresis (1 patient) to encephalopathy (2 patients). These toxicities were just as common in patients receiving preservative-free methotrexate as in those receiving methotrexate with preservative. (auth)

• Research Organization: National Cancer Inst., Bethesda, MD
• NSA Number: NSA-29-000689
• OSTI ID: 4436752
• Journal Information: Lancet, v. 2, no. 7831, pp. 703-707, Journal Name: Lancet, v. 2, no. 7831, pp. 703-707; ISSN LANCA
• Country of Publication: United Kingdom
• Language: English

Related Subjects

*LEUKEMIA-- RADIOTHERAPY
*METHOTREXATE-- TOXICITY
DOSE-RESPONSE RELATIONSHIPS
MENINGES
N48510* --Life Sciences--Radiation Effects on Animals--Man
PATIENTS
RESPONSE MODIFYING FACTORS
SIDE EFFECTS