Radiation in the treatment of meningeal leukemia

Journal Article · · Am. J. Pediatr. Hematol./Oncol.; (United States)

OSTI ID:6061221

Jenkin, R D

At the present time, a successful regimen for the eradication of occult meningeal leukemia is the combination of cranial radiotherapy in a dose of 1800 rads in 10 fractions in 12 to 14 days with six doses of intrathecal methotrexate. This regimen, when given with prednisone and vincristine can be expected to give a relapse rate for isolated meningeal leukemia of approximately 5% during the first 2 years of follow-up. A modification of this regimen utilizing craniospinal radiation with prior and concurrent intrathecal methotrexate is given for the treatment of overt meningeal leukemia at diagnosis or for an isolated first relapse with meningeal leukemia. Radiation technique and morbidity are discussed.

• Research Organization: Princess Margaret Hospital, Toronto, Ontario
• OSTI ID: 6061221
• Journal Information: Am. J. Pediatr. Hematol./Oncol.; (United States), Journal Name: Am. J. Pediatr. Hematol./Oncol.; (United States) Vol. 1:1; ISSN APHOD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ALKALOIDS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
BODY
BODY AREAS
CORTICOSTEROIDS
DISEASES
DRUGS
EVALUATION
FRACTIONATED IRRADIATION
GLUCOCORTICOIDS
HEAD
HEMIC DISEASES
HORMONES
HYDROXY COMPOUNDS
IRRADIATION
KETONES
LEUKEMIA
MEDICINE
MEMBRANES
MENINGES
METHOTREXATE
NEOPLASMS
NUCLEAR MEDICINE
ONCOVIN
ORGANIC COMPOUNDS
PREDNISONE
PREGNANES
RADIOLOGY
RADIOTHERAPY
STEROID HORMONES
STEROIDS
SURVIVAL TIME
THERAPY