Affinity of $sup 253$Es for tumour tissue

Journal Article · Wed Oct 31 23:00:00 EST 1973 · Nature (London) New Biol., v. 246, no. 149, pp. 23-25

OSTI ID:4430143

Hayes, R L; Rafter, J J; Washburn, L C; Byrd, B I

A study was made of the tissue distribution of /sup 253/Es injected as citrate (~ 10 mu Ci /sup 253/Es kg/sup -1/), or various chelates into rats beari ng Morris 5123 hepatomas and RFT tumors, and mice with transplanted P-1798 lymphosarcomas and Ca-755 adenocarcinomas. Tissue distribution of intravenously administered /sup 253/Es-citrate was essentially complete at 4 h and /sup 253/Es appeared to have an affinity for 5123C hepatomas. Tumor to non-tumor ratios in animals bearing 5123C were generally quite high (up to 96.0 in muscle) at 1 day except for liver, kidney, and bone. The other tumors showed poorer affinities, although the tumor to muscle and tumor to blood ratios were relatively high. The /sup 253/Es concentration in the kidney could not be reduced by the use of more citrate or other chelating agents. However there was some enhancement of tumor to non-tumor ratios for spleen, marrow, and blood with higher doses of citrate, or the use of nitrilotriacetic acid (NTA) or hydroxyethyliminodiacetic acid (HEIDA). (UK)

• Research Organization: Oak Ridge Associated Universities, Inc., TN
• NSA Number: NSA-29-008101
• OSTI ID: 4430143
• Journal Information: Nature (London) New Biol., v. 246, no. 149, pp. 23-25, Journal Name: Nature (London) New Biol., v. 246, no. 149, pp. 23-25; ISSN NNBYA
• Country of Publication: United Kingdom
• Language: English

Related Subjects

CITRATES
EINSTEINIUM COMPOUNDS
HEIDA
HEPATOMAS
INTRAVENOUS INJECTION
LYMPHOSARCOMAS
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
NTA
QUANTITY RATIO
RATS
TIME DEPENDENCE
TUMOR CELLS