Deuterium isotope effects in living organisms
- eds.
From 1st international conference on stable isotopes in chemistry, biology, and medicine; Argonne, Illinois, USA (9 May 1973). In proceedings of the first international conference on stable isotopes in chemistry, biology, and medicine. Deuterium isotope effects on biological systems have been studied since the separation of this isotope in 1932 and have been examined more intensively during the past 15 years. Despite the many detailed investigations of the biophysics, biochemistry, physiology, and pathology of deuterium isotope effects, there is not a full understanding as to why higher organisms fail to cope with more than 30 to 35% substitution of D/sub 2/O for H/sub 2/O in body fluids. Neither is there a preliminary comprehension of how deuterated compounds may affect the sequence of normal and of pathological events in the body. Deuterium studies on mice, rats, and dogs are reviewed. Speculation is made on the extension of these findings to man and especially to human clinical situations. (JGB)
- Research Organization:
- Division of Scientific Activities, Chicago; Argonne National Lab., Ill. (USA)
- NSA Number:
- NSA-29-000123
- OSTI ID:
- 4425530
- Report Number(s):
- CONF-730525--
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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