Acid-catalyzed deuterium exchange
- eds.
From 1st international conference on stable isotopes in chemistry, biology, and medicine; Argonne, Illinois, USA (9 May 1973). In proceedings of the first international conference on stable isotopes in chemistry, biology, and medicine. It is demonstrated that the high temperature (>200 deg C)-dilute acid exchange method presents substantial advantages over other perdeuterrtion methods (e.g., base-catalysis, metal-catalysis, concentrated acid-catalysis) because of cost, simplicity of procedure, selectivity, freedom from steric effects and side reactions, high degree of isotope incorporation, essentially quantitative yields and most impontantly, adaptability to large-scale preparations. Among the examples given are the hydration of norbornene, deuterium exchange between aniline hydrochloride and D/sub 2/O, and exchange in benzene and its derivatives as well as in benzoic acid. (JGB)
- Research Organization:
- McMaster Univ., Hamilton, Ont.; Argonne National Lab., Ill. (USA)
- NSA Number:
- NSA-29-000143
- OSTI ID:
- 4399299
- Report Number(s):
- CONF-730525--
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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