Influence of various pretreatments on the sedimentation profiles of the newly synthesized DNA after uv irradiation

Journal Article · Mon Jan 01 04:00:00 EST 1973 · Stud. Biophys., v. 36-37, pp. 113-120

OSTI ID:4423566

Slezarikova, V; Sedliakova, M

From international conference on the bases of the biological effects of ultraviolet radiation; Brno, Czechoslovakia (2 Oct 1972). Some pretreatments that inhibit DNA synthesis before ultraviolet irradiation simultaneously inhibit the excision number of surviving bacteria. Results of the influence of such pretreatments on the sedimentation profiles of the newly synthesized DNA after irradiation in the strains of Escherichia coli B//sub +/r thy/sup -/ trp/s up -/ Hcr/sup +/ and Hcr/sup -/ are presented. Pretreated Hcr/sup +/ cells were able to produce normal sized DNA after 90 minutes postincubation, while the Hcr/sup -/ cells were unable to do so, though the amounts of unexcised dimers were closely related to one another. (auth)

• Research Organization: Cancer Research Inst., Bratislava
• NSA Number: NSA-29-000593
• OSTI ID: 4423566
• Journal Information: Stud. Biophys., v. 36-37, pp. 113-120, Journal Name: Stud. Biophys., v. 36-37, pp. 113-120; ISSN STBIB
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*DNA-- CHEMICAL RADIATION EFFECTS
*ESCHERICHIA COLI-- BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
DIMERS
N48310* --Life Sciences--Radiation Effects on Microorganisms- -Basic Studies
PHOTON BEAMS
THYMINE
ULTRAVIOLET RADIATION