Parental exposure to x-irradiation and Down's syndrome

Journal Article · Wed Nov 01 04:00:00 EST 1972 · Ann. Hum. Genet., v. 36, no. 2, pp. 195-208

DOI:https://doi.org/10.1111/j.1469-1809.1972.tb00769.x· OSTI ID:4422748

Alberman, E; Polani, P E; Roberts, J A.F.; Spicer, C C; Elliott, M; Armstrong, E

The total dose of medical x irradiation ever received by 465 parents of children with Down's syndrome was compared with the corresponding dose for 465 parents of children with other severe congenital handicaps, matched for time of birth and maternal age. The mothers of those with Down's syndrome had had more total x rays, both in number and dose, before the conception, although overall the difference did not reach a significant level. However, mothers of the cases had received significantly more x rays ten years or more before the conception of the cases. No significant difference was found between the histories of the fathers of the cases and the controls. The practical and theoretical implications of the findings are discussed. (auth)

• Research Organization: Guy's Hospital Medical School, London
• NSA Number: NSA-29-000693
• OSTI ID: 4422748
• Journal Information: Ann. Hum. Genet., v. 36, no. 2, pp. 195-208, Journal Name: Ann. Hum. Genet., v. 36, no. 2, pp. 195-208; ISSN ANHGA
• Country of Publication: United Kingdom
• Language: English

Related Subjects

*DOWNS SYNDROME-- RADIOINDUCTION
AGE DEPENDENCE
BIOMEDICAL RADIOGRAPHY
CHILDREN
GONADS
N48510* --Life Sciences--Radiation Effects on Animals--Man
PROGENY
RADIATION DOSES
RADIATION HAZARDS
RADIOTHERAPY
TIME DEPENDENCE
X RADIATION