Inter-Regional, Epidemiological Study of Childhood Cancer (IRESCC): case-control study in children with germ cell tumors

Journal Article · Thu May 01 04:00:00 EDT 1986 · Carcinogenesis; (United States)

DOI:https://doi.org/10.1093/carcin/7.5.717· OSTI ID:5616677

Johnston, H E; Mann, J R; Williams, J; Waterhouse, J A; Birch, J M; Cartwright, R A; Draper, G J; Hartley, A L; McKinney, P A; Hopton, P A

In 1980-1983 members of IRESCC interviewed parents of 555 children with newly diagnosed cancer on topics of possible etiological significance. Identical questions were asked of the parents of 1100 control children chosen from hospital admissions and general practitioner lists. Medical information was confirmed whenever possible by cross-checking with NHS records. Data for the 41 children with germ cell tumors and their 82 controls are reported here. The cases had more major congenital malformations than controls, including one neural tube defect. More case than control mothers and fathers reported occupational exposure to chemicals. Nine close relatives of cases had multiple primary tumors, which were often benign or of low-grade malignancy, compared with 1 hospital control and 3 general practitioner control relatives. Cases and controls differed with respect to birth weight and paternal age. No case-control differences were shown for: birth rank, maternal age, chronic illnesses and smoking, mothers reproductive histories and oral contraceptive usage. In index pregnancies there were no case-control differences for maternal illness, infections, alcohol intake and X-ray and ultrasound exposure. There was no difference between cases and controls for the frequency of twinning the families.

• Research Organization: Queen Elizabeth Medical Centre, Birmingham, England
• OSTI ID: 5616677
• Journal Information: Carcinogenesis; (United States), Journal Name: Carcinogenesis; (United States) Vol. 5; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
CARCINOGENESIS
CHILDREN
DISEASES
EPIDEMIOLOGY
ETIOLOGY
GERM CELLS
NEOPLASMS
OCCUPATIONAL EXPOSURE
PATHOGENESIS
PREGNANCY
XENOBIOTICS