Parental radiation and Down's syndrome, with particular attention to ionizing radiation and radar. Final report

Technical Report · Wed Jun 30 04:00:00 EDT 1976

OSTI ID:6220855

Cohen, B H

To confirm or reject a possible association of Down's syndrome with maternal medical radiation and paternal radar exposure observed in a previous investigation, a replication study was conducted on parents of 300 'Current Series' cases and controls born 1962-1968 and 1945. Validation of military service and radar exposure was undertaken for all Original and Current Series fathers (involving 791 cases, controls and new matches) and chromosomes studied on 159 radar exposed and unexposed fathers. Current Series findings confirm the association with advancing maternal age and lack of a similar paternal age relationship, but show no case-control differences in parental (maternal or paternal) medical radiation or paternal radar exposure. Combining the series still yielded no significant case-control differences in fathers' radar exposure or military service, although slightly more (NSD) Army service was observed in case fathers of each series. A suggestion of more chromosome aberrancy in radar exposed fathers of the Combined Series must be interpreted with caution. Whether the apparent association indicates greater chromosome fragility with microwave exposure or is otherwise biologically meaningful, or is just spurious, requires more definitive, longitudinal studies.

• Research Organization: Johns Hopkins Univ., Baltimore, MD (USA). School of Hygiene and Public Health
• OSTI ID: 6220855
• Report Number(s): AD-A-061593
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
550900 -- Pathology
560151* -- Radiation Effects on Animals-- Man
560400 -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
CHILDREN
CHROMOSOMAL ABERRATIONS
CONGENITAL DISEASES
CONGENITAL MALFORMATIONS
DIAGNOSTIC TECHNIQUES
DISEASES
DOWNS SYNDROME
ELECTROMAGNETIC RADIATION
ETIOLOGY
FEMALES
HAZARDS
HEALTH HAZARDS
IONIZING RADIATIONS
IRRADIATION
MALES
MALFORMATIONS
MAMMALS
MAN
MEASURING INSTRUMENTS
MEDICINE
MEN
MICROWAVE RADIATION
MUTATIONS
NUCLEAR MEDICINE
PATHOLOGICAL CHANGES
PRIMATES
RADAR
RADIATION EFFECTS
RADIATION HAZARDS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RANGE FINDERS
VERTEBRATES
WOMEN