Effect of berberine on the yield of pyrimidine dimers in uv-irradiated DNA
From international conference on the bases of the biological effects of ultraviolet radiation; Brno, Czechoslovakia (2 Oct The effect of berberine on the yield of thymine dimers produced by uv light in DNA isolated from mouse leukemic cells and in DNA within irradiated cells was investigated. In solutions of isolated DNA the complete inhibition of thynnine dimerization was found at the concentration of berberine equal to 2 x 10/sup -3M/. However, in the cells inhibition of dimerization by berberine was never complete. In L cells a pronounced decrease in the intensity of DNA synthesis was found in cells treated with berberine, dependent on berberine concentration used. But despite the presence of berberine in cell nuclei, no inhibition of pyrimidine dimerization in uv irradiated cells could be established. (auth)
- Research Organization:
- Inst. of Biophysics, Brno
- NSA Number:
- NSA-29-000521
- OSTI ID:
- 4422241
- Journal Information:
- Stud. Biophys., v. 36-37, pp. 37-42, Conference: International conference on the bases of the biological effects of ultraviolet radiation, Brno, Czechoslovakia, 2 Oct 1972; Other Information: Orig. Receipt Date: 30-JUN-74
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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