Regeneration of bone marrow in rabbits following local, fractionated irradiation

Journal Article · Mon Oct 01 04:00:00 EDT 1973 · Cancer, v. 32, no. 4, pp. 847-852

DOI:https://doi.org/10.1002/1097-0142(197310)32:4<847::AID-CNCR2820320416>3.0.CO;2-V· OSTI ID:4422152

Rubin, P

Serial studies were designed to examine the in-field regeneration of bone marrow in rabbit limbs treated with various fractionated dose schedules of irradiation. The total dose levels ranged from 2,000 to 5,000 rads with doses of 200 rads/day to 1000 rads/ week. This schedule was followed to simulate the clinical setting. A double marker of /sup 99m/Tc-S colloid and /sup 59/Fe was employed to measure the activity in the reticuloendothelium (RE) and erythron compartments. The results of these studies are at variance with the published animal data, which utilized single exposures and indicated that suppression of bone marrow is permanent at doses exceeding 2,000 rads. The presented evidence indicates that bone marrow tolerance is greater for fractionated dose irradiation than for single exposures to the same levels. (auth)

• Research Organization: Univ. of Rochester, NY
• Sponsoring Organization: USDOE
• NSA Number: NSA-29-000750
• OSTI ID: 4422152
• Journal Information: Cancer, v. 32, no. 4, pp. 847-852, Journal Name: Cancer, v. 32, no. 4, pp. 847-852; ISSN CANCA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*BONE MARROW-- BIOLOGICAL REGENERATION
*LIMBS-- FRACTIONATED IRRADIATION
BIOLOGICAL RADIATION EFFECTS
IRON 59
ISOMERIC NUCLEI
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
RABBITS
RADIATION DOSES
RADIATIONS
RADIOISOTOPE SCANNING
RETICULOENDOTHELIAL SYSTEM
TECHNETIUM 99
TRACER TECHNIQUES