Bone marrow changes after localized acute and fractionated x irradiation
These studies were performed to compare the effects of single and fractionated localized irradiation doses to bone marrow on depletion and recovery of various hemopoietic cell lines. Mice received radiation to right thighs while the rest of the body was shielded. Single exposures ranged from 1000 to 10,000 rad and fractionated exposures ranged from total doses of 1000 to 6000 rad. Animals were sacrificed from 1 to 84 days after exposures. Stained sections of femurs were studied for total cellularity, megakaryocytes, immature cells (pro- and basophilic erythroblasts, myeloblasts, and promyelocytes), and lymphoid cells (lymphocytes and monocytes). In general, a dose-time-dependent response depletion pattern was seen for various cellular elements examined irrespective of the mode of radiation exposure. With fractionated schedules, all hemopoietic cell lines with the exception of megakaryocytes attained essentially control values by 12 weeks after the last radiation exposure irrespective of the total radiation dose. Megakaryocytes appeared to be less efficient in regenerating in and/or repopulating the exposed marrow. With single exposures, all hemopoietic cell lines examined failed to regenerate at radiation doses above 5000 rad.
- Research Organization:
- Brookhaven National Lab., Upton, NY
- OSTI ID:
- 6852855
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
BONE MARROW
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DATA
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXPERIMENTAL DATA
FEMUR
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
HISTOLOGY
INFORMATION
IRRADIATION
LEGS
LEUKOCYTES
LIMBS
LOCAL IRRADIATION
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MONOCYTES
NUMERICAL DATA
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RECOVERY
RODENTS
SKELETON
SOMATIC CELLS
TIME DEPENDENCE
TISSUES
VERTEBRATES