Cancer radiotherapy by combined use of radioprotectors and a radiosensitizer

Journal Article · Sat Mar 31 23:00:00 EST 1973 · Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 4, pp. 351-359

OSTI ID:4420217

Ohshima, T; Tsukiyama, I

Subcutaneous or intraperitoneal administration of 1-cysteine, 1-cysteine- d-glucose, MEA, or AET raised the survivals of male mice and decreased a loss of body weight from single or fractionated x irradiation. Among the SH compounds, AET is the most effective, and MEA is the next. In rats bearing Yoshida sarcoma, 5-flourouracil (5FU) was found to be effective as a radiosensitizer in radiation- induced depression of mitotic index of Yoshida sarcoma. Administration of MEA or 1-cysteine failed to alter the reduction of mitotic index of the sarcoma cells in rats treated with 5FU and x rays. This suggests that two SH compounds did not protect tumor cells from combined effects of 5FU and x rays. If the SH compounds exerted protective effects on normal tissues of rats, the effective killing of tumors may result in prolongation of survival times of rats bearing Yoshida sarcoma. However, the present experiments showed that the SH compounds did not prolong the survival time of the tumor-bearing rats. (auth)

• Research Organization: Tokyo Teishin Hospital
• NSA Number: NSA-29-000726
• OSTI ID: 4420217
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 4, pp. 351-359, Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 4, pp. 351-359; ISSN NHGZA
• Country of Publication: Japan
• Language: Japanese

Related Subjects

*AET-- RADIOSENSITIVITY EFFECTS
*CYSTEINE-- RADIOSENSITIVITY EFFECTS
*EXPERIMENTAL NEOPLASMS-- RADIOTHERAPY
*FLUOROURACILS-- RADIOSENSITIVITY EFFECTS
*MEA-- RADIOSENSITIVITY EFFECTS
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
MICE
MITOTIC INDEX
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
RADIATION PROTECTION
RADIOSENSITIZERS
RATS
SURVIVAL CURVES
TUMOR CELLS
WEIGHT
X RADIATION