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STUDY ON THE COMBINED EFFECT OF RADIATION AND CHEMICALS. IX. EFFECTS OF THE COMBINED USE OF X-RAY AND CARZINOPHILIN

Journal Article · · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)
OSTI ID:4044254

The effect of the combined use of x rays snd carzinophilin, an antitumor agent, was studied. Rats with Yoshida sarcoma were exposed to x irradiation of 200 r. Carzinophilin was injected intraperitoneally. Carzinophilin caussd a marked decrease in the mitotic index, but no complete recovery was found even after 3 to 4 days. Morphologically the chromosomes of Yoshida sarcoma cells showed agglutination, coalescence, fragmentation, and bridge formation, while in the cytoplasm vacuoles fect was generally increased with increasing dosage. The combined use of x rays and carzinophilin was much more effective than either used separately. (Abstr. Japan. Med., 1: No. 1, 1960)

Research Organization:
Hokkaido Univ., Sapporo
NSA Number:
NSA-15-022083
OSTI ID:
4044254
Journal Information:
Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
Country of Publication:
Country unknown/Code not available
Language:
English

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