Hematological changes after partial-body or whole-body irradiation in mice

Journal Article · Sun Apr 01 04:00:00 EST 1973 · Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 4, pp. 344-350

OSTI ID:4420122

Kojima, E; Sato, F; Tsuchihashi, S; Nakamura, W

Mice were given head, trunk, or lower body, or whole-body exposures to 500 R of x ray under anesthetic condition. Comparisons were made of the effects of these four groups of exposure on leukocyte, thrombocyte, and erythrocyte count in the circulating blood. The change in leukocyte count followed essentially the same pattern in all types of exposure, although the extent of the radiation induced reduction was more severe and the recovcry delayed in order of whole, trunk, head, lower body group. The severity of thrombocyte dcpression occurred on 6 to 10 days after exposures. It was more marked in whole-body group than in partial-body groups. No significant reduction was detectable in erythrocyte count and hematocrit value after all types of partial-body irradiation. The results suggest that precursor cells of three cell lines distribute in general uniformly in the bone marrow throughout the body. (auth)

• Research Organization: National Inst. of Radiological Sciences, Chiba, Japan
• NSA Number: NSA-29-000732
• OSTI ID: 4420122
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 4, pp. 344-350, Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 4, pp. 344-350; ISSN NHGZA
• Country of Publication: Japan
• Language: English

Related Subjects

*BLOOD PLATELETS-- BIOLOGICAL RADIATION EFFECTS
*ERYTHROCYTES-- BIOLOGICAL RADIATION EFFECTS
*LEUKOCYTES-- BIOLOGICAL RADIATION EFFECTS
ABDOMEN
BONE MARROW
HEAD
LIMBS
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PARTIAL BODY IRRADIATION
PELVIS
TIME DEPENDENCE
WHOLE-BODY IRRADIATION
X RADIATION