Life-shortening of mice by whole- or half-body x irradiation

Journal Article · Fri Jun 01 04:00:00 EDT 1973 · J. Radiat. Res., v. 14, no. 2, pp. 115-119

OSTI ID:4388024

Sato, F; Tsuchihashi, S; Kawashima, N

Four hundred seventy ddN female mice of age 10 weeks were divided into five groups; whole body exposure, head exposure, trunk exposure (chest and abdomen), lower body exposure (pelvis, legs and tail), and non-irradiated control. All the exposure groups received a single x-ray dose of Z00 R under anaesthesia. The mean survival times of five groups were 46.0 plus or minus 2.3 weeks for whole body exposure, 63.5 plus or minus 2.3 weeks for head exposure, 51.5 plus or minus 2.3 weeks for trunk exposure, 68.1 plus or minus 2.4 weeks for lower body exposure and 73.8 plus or minus 2.8 weeks for non-irradiated control. The exposure of 400 R to whole body, head, and trunk resulted in significant life- shortening from that of non-irradiated group, while the exposure to lower body did not produce any significant life-shortening. The life shortening per volume dose for head exposure group was the highest among all the exposure groups. This suggests that head (brain included) may play an important role in the radiation- induced life-shortening. (auth)

• Research Organization: National Inst. of Radiological Sciences, Chiba, Japan
• NSA Number: NSA-29-016038
• OSTI ID: 4388024
• Journal Information: J. Radiat. Res., v. 14, no. 2, pp. 115-119, Journal Name: J. Radiat. Res., v. 14, no. 2, pp. 115-119; ISSN JRARA
• Country of Publication: Japan
• Language: English

Related Subjects

*BIOLOGICAL RADIATION EFFECTS-- SURVIVAL TIME
*LIFE SPAN-- BIOLOGICAL RADIATION EFFECTS
ABDOMEN
BODY AREAS
CHEST
HEAD
LEGS
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PARTIAL BODY IRRADIATION
PHOTON BEAMS
RESPONSE MODIFYING FACTORS
WHOLE-BODY IRRADIATION
X RADIATION