Oncoprotein protein kinase

Patent · Tue Feb 25 00:00:00 EST 1997

OSTI ID:441865

Karin, M; Hibi, M; Lin, A

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE is disclosed. The polypeptide has serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences. The method of detection of JNK is also provided. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites. 44 figs.

• Research Organization: Univ. of California (United States)
• DOE Contract Number: FG03-86ER60429
• Assignee: Univ. of California, Oakland, CA (United States)
• Patent Number(s): US 5,605,808/A/
• Application Number: PAN: 8-444,393; CNN: Grant CA-50528;Grant CA-58396
• OSTI ID: 441865
• Resource Relation: Other Information: PBD: 25 Feb 1997
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
POLYPEPTIDES
PHOSPHOTRANSFERASES
ENZYME ACTIVITY
AMINO ACID SEQUENCE
PHOSPHORYLATION
GENE REGULATION
CHEMICAL COMPOSITION