The Effect of Ionizing Radiation on the Desoxyribonucleic Acid Content of Rat Thymus Nuclei

Technical Report · Thu Sep 27 00:00:00 EDT 1951

DOI:https://doi.org/10.2172/4401781· OSTI ID:4401781

Harrington, Helen ^[1]; Lavik, Paul S. ^[1]

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1. Case Western Reserve Univ., Cleveland, OH (United States)

The DNA phosphorus content per nucleus has been determined in thymus cells of normal and irradiated rats, and it has been found that irradiation causes no significant change in this value. Since there is a decrease in the DNA phosphorus concentration of thymus tissue following irradiations several mechanisms of radiation action which could cause a decrease in DNA phosphorus concentration while allowing the DNA phosphorus per nucleus to remain unchanged have been discussed. It has been suggested that an inhibition of DNA synthesis, resulting in a decreased new cell productions followed by the elimination of old lymphocytes from the thymus could account for both experimental findings.

• Research Organization: Case Western Reserve Univ., Cleveland, OH (United States)
• Sponsoring Organization: US Atomic Energy Commission (AEC)
• DOE Contract Number: W-31-109-ENG-78
• OSTI ID: 4401781
• Report Number(s): NYO--1627
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CELL NUCLEI
DNA
IRRADIATION
LYMPHOCYTES
METABOLISM
NUCLEIC ACIDS
PHOSPHORUS
QUALITATIVE ANALYSIS
QUANTITATIVE ANALYSIS
RADIATION EFFECTS
RATS
THYMUS
TISSUES
VARIATIONS