THE EFFECT OF WHOLE-BODY X-IRRADIATION ON THE GLUTATHIONE CONTENT OF RAT THYMUS

Journal Article · Wed Mar 01 04:00:00 EST 1961 · Intern. J. Radiation Biol.

DOI:https://doi.org/10.1080/09553006114550141· OSTI ID:4053961

Ashwood-Smith, M J

The reduced glutathione content of rat thymus was measured by amperometric titration. During the rapid growth of the rat the glatuthione concentration remained constant. Whole-body x-irradiation with 200 rads and 900 rads caused a significant fall in glutathione concentration apparent after 110 min. The magnitude of this fall was little affected by increased doses of x radiation, and it is unlikely that a direct radiochemical reaction was the cause of the lowered glutathione levels. These results are discussed with relation to the known sensitivity of thymus to x rays, and it is suggested that glutathione levels fall before histological evidence of death is forthcoming. The normal value for reduced glututhione per thymocyte was found to be 413 x 10/sup -12/ mu moles per cell. (auth)

• Research Organization: Medical Research Council, Harwell, Berks, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-014132
• OSTI ID: 4053961
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 3
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINO ACIDS
BIOLOGY AND MEDICINE
ELECTRIC METERS
GLANDS
GLUTATHION
QUANTITY RATIO
RADIATION EFFECTS
RADIOCHEMISTRY
RADIOSENSITIVITY
RATS
THYMUS
X RADIATION