THE EFFECT OF WHOLE-BODY X-IRRADIATION ON THE GLUTATHIONE CONTENT OF RAT THYMUS
The reduced glutathione content of rat thymus was measured by amperometric titration. During the rapid growth of the rat the glatuthione concentration remained constant. Whole-body x-irradiation with 200 rads and 900 rads caused a significant fall in glutathione concentration apparent after 110 min. The magnitude of this fall was little affected by increased doses of x radiation, and it is unlikely that a direct radiochemical reaction was the cause of the lowered glutathione levels. These results are discussed with relation to the known sensitivity of thymus to x rays, and it is suggested that glutathione levels fall before histological evidence of death is forthcoming. The normal value for reduced glututhione per thymocyte was found to be 413 x 10/sup -12/ mu moles per cell. (auth)
- Research Organization:
- Medical Research Council, Harwell, Berks, Eng.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-014132
- OSTI ID:
- 4053961
- Journal Information:
- Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 3
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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