In vivo incorporation of $sup 14$C-labelled amino acids into proteins of placenta and liver of normal and x-irradiated mice

Journal Article · Sun Jul 01 04:00:00 EDT 1973 · Indian J. Exp. Biol., v. 11, no. 4, pp. 281-284

OSTI ID:4367489

Tarachand, U; Eapen, J

Effect of x irradiation on in vivo incorporation of /sup 14/C-labeled DL- leucine, DL-phenylalanine, and glycine into placental and hepatic proteins was studied, using 15-day pregnant mice. Pattern of incorporation of leucine and phenylalanine into maternal liver proteins was similar following irradiation. Effect on glycine incorporation was different. Placental incorporation of all the three- amino acids, subsequent to irradiation, was comparable. Starvation per se enhanced incorporation of leucine into hepatic proteins which was further elevated following irradiation. Placental incorporation was reduced by starvation. Subcellular fractions showed disparate changes in leucine incorporation due to irradiation. Acid-soluble pool changed, following irradiation, without significantly affecting incorporation of the precursors into proteins. (auth)

• Research Organization: Bhabha Atomic Research Centre, Bombay
• NSA Number: NSA-29-018637
• OSTI ID: 4367489
• Journal Information: Indian J. Exp. Biol., v. 11, no. 4, pp. 281-284, Journal Name: Indian J. Exp. Biol., v. 11, no. 4, pp. 281-284; ISSN IJEBA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*GLYCINE-- UPTAKE
*LEUCINE-- UPTAKE
*LIVER-- BIOLOGICAL RADIATION EFFECTS
*PHENYLALANINE-- UPTAKE
*PLACENTA-- BIOLOGICAL RADIATION EFFECTS
*PROTEINS-- BIOSYNTHESIS
CARBON 14 COMPOUNDS
IN VIVO
MICE
N48140 --Life Sciences--Radiation Effects on Biochemicals--In Animals
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
PREGNANCY
WHOLE-BODY IRRADIATION
X RADIATION