Synthesis of RNA in saccharomyces after photodynamic treatment or irradiation with x rays

Journal Article · Mon Oct 01 04:00:00 EDT 1973 · Biophysik, v. 10, no. 3, pp. 249-256

OSTI ID:4357941

Micheler, A; Pietsch, I; Lochmann, E R

RNA synthesis in Saccharomyces was investigated up to 10 h after x- irradiation or photodynamic treatment with thiopyrorine and visible light. Even with high doses of x rays RNA synthesis is only very slightly inhibited in all cells up to about 2 h after irradiation. Then RNA synthesis decreases strongly in cells that cannot divide. On the contrary, after photodynamic treatment the inhibition of RNA synthesis in cells which lost their colony-forming ability begins immediately. In cells not inactivated in colony-forming ability, RNA synthesis shows nearly the same extent as control cells. These results give further supports that inactivation by photodynamic action in yeast cells is not caused by DNA damage, which is the case after irradiation with x rays, but by inactivating plasmatic stractures. (GE)

• Research Organization: Freie Univ., Berlin
• NSA Number: NSA-29-015901
• OSTI ID: 4357941
• Journal Information: Biophysik, v. 10, no. 3, pp. 249-256, Journal Name: Biophysik, v. 10, no. 3, pp. 249-256; ISSN BPYKA
• Country of Publication: Germany
• Language: German

Related Subjects

*RNA-- BIOSYNTHESIS
*SACCHAROMYCES-- BIOLOGICAL RADIATION EFFECTS
CFU
INHIBITION
N48310* --Life Sciences--Radiation Effects on Microorganisms- -Basic Studies
PHOTON BEAMS
VISIBLE RADIATION
X RADIATION