SYNTHESIS OF PROTEIN, RNA, DNA AND INDUCED ENZYME IN BACTERIUM CADAVERIS AFTER X-IRRADIATION

Journal Article · Fri Mar 01 04:00:00 EST 1963 · Intern. J. Radiation Biol.

OSTI ID:4716159

Pauly, H

Findings are presented on the x-ray inhibition of total protein- synthesis, the induced synthesis of lysine decarboxylase, RNA- and DNA-formation and colony-formation of Bacterium cadaveris immediately after x irradiation. The rate of protein-, enzyme- and RNA-formation is an exponential function of dose with practically the same inactivation dose of 30 kr. It is concluded that the block of RNA-formation is responsible for the inhibition of protein synthesis. The colony-forming ability was found to be three times more radiosensitive. The D/sub 37/ of the exponential survival-curve is about 10 kr. DNA-formation shows a prolongation of the time-lag after x irradiation. The oxygen-enhancement factor is roughly the same for all functions tested and lies in the neighborhood of 4. (auth)

• Research Organization: Max-Planck-Institut fur Biophysik, Frankfurt am Main
• NSA Number: NSA-17-027109
• OSTI ID: 4716159
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 6
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BACTERIA
BACTERIUM CADAVERIS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
ENZYMES
NUCLEIC ACIDS
OXYGEN
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
RIBONUCLEIC ACID
X RADIATION