Regeneration of gastric glandular epithelium in adult mice after exposure to 1-MeV fast neutrons

Book · Mon Jan 01 04:00:00 EST 1973

OSTI ID:4348128

Davids, J A.G.

A severe destruction of the glandular epithelium of the stomach develops after whole-body irradiation of mice with fast neutrons in the upper lethal and supralethal dose-range. In the first week after exposure the cells decrease in number especially in the gastric pits. In the second week extensive necrosis of cells occurs in the fundic glands. Cellular proliferation starts in the isthmus region of the glands. The regeneration of the epithelium of the gastric pits proceeds quickly and at the end of the second week a new layer of surface epithelial cells has been formed. The regeneration of the epithelium of the fundic glands proceeds more slowly. First, a continuous layer of mucous neck cells is formed during the third week. In the fourth week a layer of parietal cells grows between the basal membrane and the mucous neck cells and finally zymogenic cells differentiate in the bottom of the glands within six weeks after irradiation. The results show that even after a severe generalized destruction, the glandular epithelium of the stomach in the adult organism has preserved the potential of full regeneration. (GE)

• Research Organization: Stichting Reactor Centrum Nederland, Petten
• NSA Number: NSA-29-015990
• OSTI ID: 4348128
• Country of Publication: Germany
• Language: English

Related Subjects

*EPITHELIUM-- BIOLOGICAL REGENERATION
*STOMACH-- BIOLOGICAL RADIATION EFFECTS
ANIMAL CELLS
CELL PROLIFERATION
FAST NEUTRONS
LETHAL IRRADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
NECROSIS
NEUTRON BEAMS
SUPRALETHAL IRRADIATION