Regeneration of gastric glandular epithelium in adult mice after exposure to 1-MeV fast neutrons
A severe destruction of the glandular epithelium of the stomach develops after whole-body irradiation of mice with fast neutrons in the upper lethal and supralethal dose-range. In the first week after exposure the cells decrease in number especially in the gastric pits. In the second week extensive necrosis of cells occurs in the fundic glands. Cellular proliferation starts in the isthmus region of the glands. The regeneration of the epithelium of the gastric pits proceeds quickly and at the end of the second week a new layer of surface epithelial cells has been formed. The regeneration of the epithelium of the fundic glands proceeds more slowly. First, a continuous layer of mucous neck cells is formed during the third week. In the fourth week a layer of parietal cells grows between the basal membrane and the mucous neck cells and finally zymogenic cells differentiate in the bottom of the glands within six weeks after irradiation. The results show that even after a severe generalized destruction, the glandular epithelium of the stomach in the adult organism has preserved the potential of full regeneration. (GE)
- Research Organization:
- Stichting Reactor Centrum Nederland, Petten
- NSA Number:
- NSA-29-015990
- OSTI ID:
- 4348128
- Resource Relation:
- Conference: Symposium on the effects of neutron irradiation upon cell function, Nuremburg, Germany, 22 Oct 1973; Other Information: Orig. Receipt Date: 30-JUN-74; Bib. Info. Source: GE (GE)
- Country of Publication:
- Germany
- Language:
- English
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