GASTRIC LESIONS IN EXPERIMENTAL ANIMALS FOLLOWING SINGLE EXPOSURES TO IONIZING RADIATIONS

Journal Article · Wed Jan 01 04:00:00 EST 1958 · American Journal of Pathology (U.S.)

OSTI ID:4332732

Brecher, G; Cronkite, E P; Conard, R A; Smith, W W

Epithelial changes in the gastric mucosa of dogs, rats, and hamsters developed following singie supralethal exposures to irradiation. These changes were quite simllar ine. Regeneration proceeded from the neck of the glands and was comparable to the regeneration of small intestine mucosa from surviving crypt epithelium. Occasionally, the direct damage was severe enough to lead to ulceration, even after local irradiation and in the absence of agranulocytosis and hemorrhage. This was in contrast to the late ulcers appearing in the regenerated mucosa of the small intestine which were associated with hemorrhage or represented direct sequelae of the pancytopenia that follows lethal irradiation. (auth)

• Research Organization: National inst. of Arthritis and Metabolic Diseases. National Cancer Inst., Naval Medical Research Inst., Bethesda, Md.; Brookhaven National Lab., Upton, N.Y.
• NSA Number: NSA-12-008256
• OSTI ID: 4332732
• Journal Information: American Journal of Pathology (U.S.), Journal Name: American Journal of Pathology (U.S.) Vol. Vol: 34; ISSN AJPAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMALS
BIOLOGY AND MEDICINE
BLOOD CELLS
DISEASES
DOGS
GLANDS
HAMSTERS
HEMORRHAGE
INTESTINE
IRRADIATION
LETHAL DOSE
RADIATION INJURIES
RATS
REGENERATION
STOMACH
TISSUES
ULCERS