Mechanism of radioprotection by cysteamine. I. Relationship between cysteamine-induced mitotic inhibition and radioprotective effects in the livers of young and senile white mice

Journal Article · Mon Oct 01 04:00:00 EDT 1973 · Int. J. Radiat. Biol., v. 24, no. 4, pp. 329-337

OSTI ID:4347940

Mitznegg, P; Saebel, M

The incorporation of /sup 3/H--thymidine into liver, DNA, the weight of the liver, its DNA-, RNA-, and protein content, and body-weight were investigated in white NMRI mice at the age of five weeks or two years aft er (1) intraperitoneal application of 150 mg/kg cysteamine, (2) whole-body irradiation with 500 rads /sup 60/Co gamma rays, (3) combined application of cysteamine and irradiation. The i.p. application of cysteamine resulted in a transient decrease of the /sup 3/H-thymidine incorporation into liver DNA of the five-week-old mice. in two-year-old animals, the incorporation rate was temporarily increased; partial hepatectomy, however, resulted in a decrease similar to that in the young animals. Whole-body irradiation caused an initial decrease of the incorporation rate in both animal groups; subsequently it increased and reached the control values after seven days. At this time, however, the DNA-, RNA-, and protein content was significantiy lower in the irradiated animals. Cysteamine given 15 min before irradiation accelerated the recovery processes in the young animals; but in two-year-old mice it was ineffective. A good correlation was seen between the transient DNA inhibition initiated by cysteamine in proliferative liver tissue and the cysteamine-induced acceleration of the recovery processes in the liver. (auth)

• Research Organization: Univ., Erlangen-Nuernberg, Ger.
• NSA Number: NSA-29-016002
• OSTI ID: 4347940
• Journal Information: Int. J. Radiat. Biol., v. 24, no. 4, pp. 329-337, Journal Name: Int. J. Radiat. Biol., v. 24, no. 4, pp. 329-337; ISSN IJRBA
• Country of Publication: United Kingdom
• Language: English

Related Subjects

*LIVER-- BIOLOGICAL RADIATION EFFECTS
*MEA-- RADIOSENSITIVITY EFFECTS
AGE DEPENDENCE
BIOLOGICAL RECOVERY
COBALT 60
DNA
GAMMA RADIATION
INTRAPERITONEAL INJECTION
METABOLISM
MICE
MITOSIS
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
NUCLEOSIDES
PHOTON BEAMS
PROTEINS
RNA
TIME DEPENDENCE
TRITIUM COMPOUNDS
WHOLE-BODY IRRADIATION