Concentration of leucogenenol in the serum of dogs following their exposure to lethal $gamma$ radiation from cobalt-60

Journal Article · Sat Dec 01 04:00:00 EST 1973 · Radiat. Res., v. 56, no. 3, pp. 507-512

OSTI ID:4347462

Rice, F A; Chen, C G; Rene, A A

>Three male and 3 female dogs were exposed in the AFRRI whole body irradiator to 350 rads of cobalt-60 gamma -radiation at approximately 39.5 rads/ min. Prior to and at intervals following irradiation, a sample of serum was obtained from each dog and assayed for its leucogenenol content. Before irradiation the average concentration of leucogenenol in the serum was 10.5 plus or minus 6 mu g/liter. The day after irradiation the average concentration in 5 dogs fell to 0.002 mu g/liter and in 1 dog to 1.5 mu g/liter. However, 2 days after irradiation the average concentration in all dogs was elevated to 41 plus or minus 10 mu g/liter. The concentration of leucogenenol in the serum then declined so that 7 days after irradiation it was 0.47 plus or minus 0.24 mu g/liter. Leucogenenol was not measureable (< 0.001 mu g/liter) in each dog's serum for approximately 4 days before the dog died. Individual dogs survived for from 1;3 to 20 days after irradiation. (auth)

• Research Organization: American Univ., Washington, DC
• NSA Number: NSA-29-016025
• OSTI ID: 4347462
• Journal Information: Radiat. Res., v. 56, no. 3, pp. 507-512, Journal Name: Radiat. Res., v. 56, no. 3, pp. 507-512; ISSN RAREA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*ENOLS-- BIOLOGICAL RADIATION EFFECTS
*LEUCOGENENOL-- BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
DOGS
GAMMA RADIATION
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
QUANTITY RATIO LEUCOGENENOL