Effects of papaverine and isoproterenol on the regional distribution of myocardial blood flow in dogs

Conference · Mon Apr 01 04:00:00 EDT 1974 · Radiology, v. 111, no. 1, pp. 157-160

OSTI ID:4311229

Moore, R; Rizk, G; Loken, M; Amplatz, K

From 58th sctentific assembly and annual meeting of the Radiological Society of North America; Chicago, IL (26 Nov 1972). The left anterior descending coronary artery was catheterized in dogs and 5 mCi of /sup 133/Xe dissolved in 1 ml of isotonic saline was injected and flushed with 3 ml of isotonic saline. Regional myocardial blood flow rates were measured with a gamma camera before and after the administration of 500 mu g/kg of papaverine or 10 mu g/kg of isoproterenol. The average myocardial blood flow rate was 107 plus or minus 13 (12%) ml/min/100 g of myocardium before the injection of papaverine and 190 plus or minus 16 (9%) ml/min/100 g afterward. There was no difference in the ratc of flow before or after the administration of isoproterenol. (auth)

• Research Organization: Univ. of Minnesota, Minneapolis
• NSA Number: NSA-29-029930
• OSTI ID: 4311229
• Conference Information: Journal Name: Radiology, v. 111, no. 1, pp. 157-160
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*BLOOD FLOW-- TRACER TECHNIQUES
*DRUGS-- BIOLOGICAL EFFECTS
*MYOCARDIUM-- BLOOD FLOW
DOGS
GAMMA CAMERAS
N48830* --Life Sciences--New Tracer Techniques--Other
RADIOISOTOPE SCANNING
XENON 133