THE EFFECTS OF HEAVY GAMMA IRRADIATION UPON PITUITARY GLANDS TRANSPLANTED INTO HYPOPHYSECTOMIZED TADPOLES OF BUFO BOREAS
The pituitary gland retains its ability to secrete thyrotrophic hormone and intermedin up to 108 days after very heavy irradiation. In these experiments hypophysectomy had been performed as usual on tadpoles at the tail bud stage and the pituitary glands of irradiated recently metamorphosed toads were transplanted into them after they had reached a trunk length of 6 to 6 mm. The activity of the transplant was largely conditioned by the anount of trauma that occurred in the operation. In more favorable cases the pars anterior produced thyrotrophic hormone sufficient to induce the thyroid gland of the hosts to secrete enough hormone to cause well advanced development toward metamorphosis by the end of 42 days. Tadpoles killed at 106 days show still further average development. The thyrotrophic function of the pars anterior was maintained after an irradiation of 27,000 r but it is probable that a still heavier irradiation would not have completely destroyed its capacity to secrete during this period of time. Color change induced by the secretory activity of the pars intermedia is very pronounced at 45 minutes after transplantation and continues through the 106 days of the experiment. These color effects are fully maintained in spite of an irradiation of 27,000 r only slight diminution resulting from a dosage of 40,000 r. (auth)
- Research Organization:
- Univ. of California at Los Angeles
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-12-011243
- OSTI ID:
- 4339540
- Journal Information:
- J. Exptl. Zool, Journal Name: J. Exptl. Zool Vol. Vol: 136, No. 1
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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