Excretion of 5-hydroxyindoleacetic acid in patients irradiated therapeutically

Journal Article · Thu Nov 01 04:00:00 EST 1973 · Int. J. Radiat. Biol., v. 24, no. 5, pp. 443-448

DOI:https://doi.org/10.1080/09553007314551321· OSTI ID:4337744

Pericic, D; Deanovic, Z

The 24-hr urinary excretion of 5-hydroxyindoleacetic acid (5HIAA) was determined in patients suffering from genital carcinoma, who had been irradiated therapeutically with gamma rays from intracavitary radium sources and/or with x rays. Radium was applied for 46 hrs, twice within two weeks. X radiation was delivered on two anterior and two posterior abdominal fields, 800 R daily in the source of l5 days. The values of 5-HIAA obtained in periods of irradiation were compared with control values (before irradiation) in the same patients. Creatinine was also determined. In most patients treated with radium, there was a depression in 5-HIAA excretion only during -the treatment; after removal of the radium, there was a slight increase. The excretion of creatinine in these patients was not constant. The increased urinary 5-HIAA excretion was observed also in three out of five x-irradiated patients. The results are discussed with regard to the data published previously. (auth)

• Research Organization: Rudjer Boskovic Inst., Zagreb
• NSA Number: NSA-29-015945
• OSTI ID: 4337744
• Journal Information: Int. J. Radiat. Biol., v. 24, no. 5, pp. 443-448, Journal Name: Int. J. Radiat. Biol., v. 24, no. 5, pp. 443-448; ISSN IJRBA
• Country of Publication: United Kingdom
• Language: English

Related Subjects

*CARBOXYLIC ACIDS-- EXCRETION
*CREATININE-- EXCRETION
*RADIOTHERAPY- - SIDE EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
DOSE-RESPONSE RELATIONSHIPS
FEMALE GENITALS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HYDROXY COMPOUNDS
INDOLES
N48510* --Life Sciences--Radiation Effects on Animals--Man
PHOTON BEAMS
RADIUM
TIME DEPENDENCE
URINE
WOMEN
X RADIATION