RELATIONSHIP BETWEEN THE DOSE OF WHOLE-BODY X-IRRADIATION AND THE URINARY EXCRETION OF 5-HYDROXYINDOLEACETIC ACID IN RATS

Journal Article · Mon Jul 01 04:00:00 EDT 1963 · Intern. J. Radiation Biol.

DOI:https://doi.org/10.1080/09553006314550781· OSTI ID:4024145

Deanovic, Z; Supek, Z; Randic, M

The dependency on x irradiation dose of urinary excretion of 5- hydroxyindoleacetic acid (5-HIAA) in rats was studied. A significant positive correlation between the applied doses: 50, 100, 150, 200, 400, 600, and 800 r, and 5-HIAA excretion-rate was found. By means of this biochemical test it is possibie to discriminate between animals irradiated with low (50, 100, 150 r), medium (200, 400 r) and high (800, 800 r) doses. The maximal increase of 5-HIAA output after irradiation appeared during the first 24 hours; excretion returned to normal values on the third day after irradiation. The females showed a more pronounced response to radiation than the males. The dose of 200 r seemed to be the lowest that significantly increases the output of 5-HIAA. The rats pretreated with sub-lethal doses (50--200 r) responded to the subsequent dose of 800 r with somewhat delayed reaction. Some other urinary substances showing a certain irradiation dose-dependency were compared with 5-HIAA; the latter appears to be a good indicator for the evaluation of absorbed radiation dose. (auth)

• Research Organization: Institut Rudjer Boskovic, Zagreb
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-019626
• OSTI ID: 4024145
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 7
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACETIC ACID
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BODY
HYDROXIDES
INDOLES
IRRADIATION
LETHAL DOSE
METABOLISM
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
QUANTITATIVE ANALYSIS
RADIATION DOSES
RADIATION EFFECTS
RATS
RECOVERY
SEX
URINE
VARIATIONS
X RADIATION