EFFECT OF CHEMOPROTECTION BY CYSTAMINE ON URINARY EXCRETION OF 5- HYDROXYINDOLEACETIC ACID IN X-IRRADIATED RATS

Journal Article · Mon Jul 01 04:00:00 EDT 1963 · Intern. J. Radiation Biol.

DOI:https://doi.org/10.1080/09553006314550941· OSTI ID:4024093

Deanovic, Z; Supek, Z; Bulat, M

Studies were made on the excretion of 5-HIAA in the urine of lethally irradiated rats protected with a chemoprotector that is not a 5-hydroxyindole. It was concluded that cystamine produces inhibition of the post-irradiation increase in urinary excretion of 5-HIAA in rats but that inhibition is incomplete. Three possible explanations are given: cystamine prevents the discharge of 5-HT from body depots; it deviates the metabolic pathway of 5-HT; or inhibits the renal tubular secretion of 5-HIAA. (P.C.H.)

• Research Organization: Institut Rudjer Boskovic, Zagreb
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-019639
• OSTI ID: 4024093
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 7
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACETIC ACID
AMINES
BIOCHEMISTRY
BIOLOGY AND MEDICINE
ETHYL RADICALS
HYDROXIDES
INDOLES
IRRADIATION
KIDNEYS
LETHAL DOSE
MEA
MEASURED VALUES
METABOLISM
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHYSIOLOGY
QUANTITATIVE ANALYSIS
RADIATION EFFECTS
RADIATION PROTECTION
RATS
SEROTONIN
URINE
X RADIATION